Wadih Arap Selected Research

Peptidomimetics

1/2017	BMTP-11 is active in preclinical models of human osteosarcoma and a candidate targeted drug for clinical translation.
10/2015	The peptidomimetic Vasotide targets two retinal VEGF receptors and reduces pathological angiogenesis in murine and nonhuman primate models of retinal disease.
7/2015	Targeting the interleukin-11 receptor α in metastatic prostate cancer: A first-in-man study.
7/2015	Targeting IL11 Receptor in Leukemia and Lymphoma: A Functional Ligand-Directed Study and Hematopathology Analysis of Patient-Derived Specimens.
4/2013	Inhibition of established micrometastases by targeted drug delivery via cell surface-associated GRP78.
2/2013	Mechanism of action and initial evaluation of a membrane active all-D-enantiomer antimicrobial peptidomimetic.
1/2013	An antimicrobial peptidomimetic induces Mucorales cell death through mitochondria-mediated apoptosis.
11/2011	A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys.
4/2008	Combinatorial targeting of the macropinocytotic pathway in leukemia and lymphoma cells.
10/2007	Treatment of hypoxia-induced retinopathy with targeted proapoptotic peptidomimetic in a mouse model of disease.

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Wadih Arap Research Topics

Disease

99	Neoplasms (Cancer) 03/2022 - 02/2002
21	Neoplasm Metastasis (Metastasis) 01/2021 - 12/2002
18	Prostatic Neoplasms (Prostate Cancer) 12/2019 - 02/2002
8	Breast Neoplasms (Breast Cancer) 07/2021 - 09/2004
8	Infections 06/2021 - 04/2005
6	Leukemia 07/2015 - 04/2003
5	Obesity 01/2020 - 06/2009
5	Melanoma (Melanoma, Malignant) 02/2016 - 10/2008
4	Glioblastoma (Glioblastoma Multiforme) 01/2020 - 04/2010
4	Inflammation (Inflammations) 12/2019 - 08/2006
4	Carcinogenesis 09/2010 - 02/2009
3	COVID-19 08/2021 - 01/2021
3	Colorectal Neoplasms (Colorectal Cancer) 01/2021 - 11/2012
3	Weight Loss (Weight Reduction) 01/2020 - 11/2011
3	Atherosclerosis 12/2018 - 12/2002
3	Osteosarcoma (Osteogenic Sarcoma) 01/2017 - 03/2009
3	Neuroblastoma 10/2015 - 07/2010
3	Lymphoma (Lymphomas) 07/2015 - 04/2008
3	Transitional Cell Carcinoma 01/2015 - 04/2003
3	Hypoxia (Hypoxemia) 02/2014 - 02/2004
3	Emphysema 08/2009 - 08/2006
2	Triple Negative Breast Neoplasms 03/2022 - 01/2021
2	Chagas Disease (American Trypanosomiasis) 12/2021 - 06/2021
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 06/2010
2	Carcinoma (Carcinomatosis) 01/2018 - 04/2003
2	Multiple Myeloma 10/2017 - 01/2004
2	Lung Neoplasms (Lung Cancer) 01/2016 - 03/2015
2	Retinal Diseases 10/2015 - 10/2007
2	Necrosis 06/2013 - 10/2002
2	Disease Progression 05/2011 - 01/2003
2	Retinopathy of Prematurity (Retrolental Fibroplasia) 03/2010 - 10/2007
2	Sarcoma (Soft Tissue Sarcoma) 04/2009 - 03/2008
1	Brain Concussion (Cerebral Concussion) 01/2022

Drug/Important Bio-Agent (IBA)

44	LigandsIBA 03/2021 - 12/2002
42	Peptides (Polypeptides)IBA 03/2021 - 02/2002
27	Proteins (Proteins, Gene)FDA Link 03/2022 - 08/2003
26	Pharmaceutical PreparationsIBA 01/2021 - 02/2002
13	Peptide LibraryIBA 12/2021 - 02/2004
11	PeptidomimeticsIBA 01/2017 - 11/2005
10	1-(1-mercaptocyclohexaneacetic acid)-2-(O- methyl-L-tyrosine)-8-L-arginine- vasopressin (AAVP)IBA 03/2021 - 04/2006
10	Endoplasmic Reticulum Chaperone BiPIBA 12/2018 - 09/2004
9	Biological ProductsIBA 01/2021 - 06/2009
9	AntibodiesIBA 01/2018 - 02/2002
8	IntegrinsIBA 01/2020 - 08/2004
7	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 09/2004
7	Interleukin-11 Receptors (Interleukin 11 Receptor)IBA 01/2017 - 12/2002
5	Biomarkers (Surrogate Marker)IBA 01/2019 - 02/2015
5	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2016 - 02/2002
5	CD13 Antigens (Alanine Aminopeptidase)IBA 12/2013 - 12/2002
4	VaccinesIBA 08/2021 - 01/2017
4	EpitopesIBA 06/2021 - 05/2011
4	AntigensIBA 06/2021 - 07/2010
4	CytokinesIBA 01/2021 - 01/2008
4	AutoantibodiesIBA 12/2018 - 01/2010
4	Monoclonal AntibodiesIBA 01/2018 - 02/2004
4	bone metastasis-targeting peptidomimetic-11IBA 01/2017 - 07/2015
4	Thymidine KinaseIBA 11/2016 - 03/2008
3	Cell Surface ReceptorsIBA 01/2017 - 10/2016
3	Liposomes (Liposome)IBA 02/2016 - 07/2010
3	AndrogensIBA 03/2015 - 07/2013
3	Indicators and Reagents (Reagents)IBA 02/2015 - 11/2005
3	Neoplasm Antigens (Tumor Antigens)IBA 02/2015 - 11/2004
2	MicroRNAs (MicroRNA)IBA 03/2022 - 06/2010
2	IronIBA 07/2021 - 01/2011
2	InterferonsIBA 02/2021 - 11/2020
2	Cysteine (L-Cysteine)FDA Link 01/2021 - 05/2006
2	Molecular Chaperones (Chaperone, Molecular)IBA 12/2018 - 12/2017
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2018 - 07/2016
2	Prostate-Specific Antigen (Semenogelase)IBA 12/2017 - 07/2013
2	Immunoglobulin G (IgG)IBA 10/2017 - 02/2010
2	Immunoglobulins (Immunoglobulin)IBA 10/2017 - 01/2015
2	Long Noncoding RNAIBA 10/2017 - 07/2015
2	Myeloblastin (Proteinase 3)IBA 01/2017 - 11/2011
2	Interleukin-11 (Interleukin 11)IBA 01/2017 - 01/2008
2	Annexin A2 (Annexin II)IBA 01/2017 - 11/2011
2	Ganciclovir (Cytovene)FDA LinkGeneric 11/2016 - 08/2009
2	ProdrugsIBA 11/2016 - 05/2004
2	Silicon Dioxide (Silica)FDA LinkGeneric 10/2016 - 02/2016
2	Antineoplastic Agents (Antineoplastics)IBA 02/2016 - 05/2013
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2015 - 03/2006
2	Retinaldehyde (Retinal)IBA 10/2015 - 10/2007
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 03/2015 - 05/2013
2	Protein Isoforms (Isoforms)IBA 02/2015 - 02/2002
2	Oxygen (Dioxygen)IBA 02/2014 - 03/2007
2	Doxorubicin (Adriamycin)FDA LinkGeneric 09/2013 - 07/2010
2	Anti-Bacterial Agents (Antibiotics)IBA 02/2013 - 01/2013
2	Cadherins (E-Cadherin)IBA 11/2012 - 11/2005
2	NGR peptideIBA 09/2012 - 10/2008
2	ErbB Receptors (EGF Receptor)IBA 01/2011 - 03/2010
2	Glutamyl Aminopeptidase (Aspartyl Aminopeptidase)IBA 07/2010 - 02/2004
2	Peptide Hydrolases (Proteases)FDA Link 08/2006 - 02/2004
1	Phosphotransferases (Kinase)IBA 03/2022
1	6-(trifluoroacetamido)-1-hexanoicanilideIBA 01/2022

Therapy/Procedure

44	Therapeutics 11/2021 - 02/2002
6	Drug Therapy (Chemotherapy) 01/2021 - 01/2008
4	Precision Medicine 01/2021 - 08/2016
3	Immunotherapy 11/2021 - 02/2010
2	Aftercare (After-Treatment) 01/2020 - 09/2011
2	Castration 11/2016 - 07/2013
2	Radiotherapy 03/2015 - 05/2011